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Cialis tablets

Instructions for use and annotation to the drug, reviews about the drug CIALIS tablets, minimum cost, packaging photo, CIALIS analogues, side effects, indications for use and contraindications

An agent for the treatment of erectile dysfunction, is a reversible selective inhibitor of specific PDE5 cGMP. When sexual arousal causes local release of nitric oxide, PDE5 inhibition by tadalafil results in an increase in cGMP levels in the corpus cavernosum of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries best place to buy levitra 10mg and the flow of blood to the tissues of the penis, which causes an erection. Tadalafil is ineffective in the absence of sexual stimulation.

In vitro studies have shown that tadalafil is a selective PDE5 inhibitor. PDE5 – an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of internal organs, in skeletal muscles, platelets, kidneys, lungs, cerebellum.

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The effect of tadalafil on PDE5 is more active than on other phosphodiesterases. Tadalafil is 10,000 times more active against PDE5 than against PDE1, PDE2, PDE4, which are localized in the heart, brain, blood vessels, liver and other organs. Tadalafil is 10,000 times more active at blocking PDE5 than PDE3, an enzyme found in the heart and blood generic cialis india vessels. This selectivity for PDE5 over PDE3 is important because PDE3 is an enzyme involved in cardiac muscle contraction. In addition, tadalafil is approximately 700 times more active against PDE5 than against PDE6, which is found in the retina and is responsible for phototransmission. Tadalafil is also 10,000 times more potent against PDE5 compared to its effect on PDE7-PDE10.

Effective for 36 hours. The effect appears already 16 minutes after ingestion in the presence of sexual arousal.

Tadalafil in healthy individuals does not cause a significant change in systolic and diastolic pressure, compared with placebo in the supine position (the average maximum decrease is 1.6 / 0.8 mm Hg, respectively) and standing (the average maximum decrease is 0.2 / 4.6 mm Hg. Art. respectively). Tadalafil does not cause a significant change in heart rate.

Tadalafil does buy sildenafil 100mg online not cause changes in color recognition (blue / green), which is explained by its low affinity for PDE6. In addition, there is no effect of tadalafil on visual acuity, electroretinogram, intraocular pressure and pupil size..

There was no clinically significant effect on sperm characteristics in men who took tadalafil at daily doses for 6 months..

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